In "Walk Away Renee," The Four Tops sings about a man who is desperately trying to forget Renee, the object of his affection. The song's chorus tells her to walk away and that she won't see him following her home. The narrator reminisces about places they used to pass by daily, but now those same locations only remind him of Renee. He's in so much pain that he has to hide it from others. Even though the relationship may be over, their names on a wall together continue to remind him of their love. He knows Renee is not to blame for this heartache, but he must let her go.

The song is an expression of unrequited love and heartbreak. Despite the narrator's best efforts to move on, he still finds himself thinking about Renee. The mention of the "sign that points one way" and "the lot we used to pass by every day" suggests that the two of them had a routine or certain places they went to, which now have become difficult to visit. The line "from deep inside the tears I'm forced to cry, from deep inside the pain that I chose to hide" suggests that the narrator is trying to maintain a façade of strength, even though he's deeply affected by the breakup.