I Want A New Drug/Small World
Huey Lewis & The News Lyrics

I want a new drug
The singer is expressing a desire to find a different type of drug than what he currently uses.

One that won't make me sick
He wants a drug that won't have harmful physical effects.

One that won't make me crash my car
He wants a drug that won't impair his motor functions to the point of causing accidents.

Or make me feel three feet thick
He wants a drug that won't give him a heavy, sluggish feeling in his body.

One that won't hurt my head
He wants a drug that won't give him headaches or migraines.

One that won't make my mouth too dry
He wants a drug that won't cause dehydration or dry mouth.

Or make my eyes too red
He wants a drug that won't give him noticeable physical side effects, like red eyes.

One that won't make me nervous
He wants a drug that won't cause anxiety or paranoia.

Wondering what to do?
He doesn't want to feel confused or unsure of himself.

One that makes me feel like I feel when I'm with you
He wants the drug to give him the same positive feelings and sensations that he gets when he's with someone special (presumably a romantic partner).

When I'm alone with you
He wants to experience these feelings even when he's not with that person.

One that won't spill
He wants a drug that's easy to transport and won't create a mess.

One that don't cost too much
He wants a drug that's affordable and won't break the bank.

Or come in a pill
He wants a drug that doesn't necessarily have to come in the form of a capsule or tablet.

One that won't go away
He wants the effects of the drug to last for a long time.

One that won't keep me up all night
He doesn't want the drug to affect his sleep schedule or cause insomnia.

One that won't make me sleep all day
He also doesn't want to feel lethargic or fatigued because of the drug.

One that does what it should
He wants the drug to deliver its intended effects consistently.

One that won't make me feel too bad
He wants to avoid drugs that have negative physical or emotional side effects.

One that won't make me feel too good
He might be concerned that a drug that feels too pleasurable could be addictive or lead to unhealthy behavior.

One with no doubt
He wants a drug that's dependable and safe to use.

One that won't make me talk too much
He wants to avoid drugs that affect his behavior or make him overly talkative.

Or make my face break out
He wants to avoid any drugs that could cause him to experience physical side effects, like rashes or acne.

I'm alone with you yea yea
He's emphasizing his desire to have the same positive experience with the new drug that he does with being in the company of his partner.