The lyrics of John Mayer’s “Vultures” delve into the idea of fighting through difficult and trying times, when external forces are trying to break one’s spirit. The first verse is very straight forward, discussing the idea that some people are always around while others seem to disappear. It highlights the idea that each person has their own way of dealing with life’s challenges, but ultimately, we all wonder how we can prevent becoming a faceless number within society.

The chorus of the song reiterates the fact that life can be hard, and it feels as if the world is constantly testing us. The reference to "vultures" indicates the people who are always willing to pick at our carcasses when we’re at our most vulnerable, wanting to stake their claim on what is left behind.

The second verse revisits the idea of vultures, only this time they appear to be surrounding the songwriter's personal space like they're waiting for him to face a difficult moment so they can take advantage of him. It's almost as if they derive pleasure from their misfortune. The lyrics "All of these vultures hiding/Right outside my door/I hear them whisperin'" demonstrate the anxiety that comes with being visibly vulnerable. Even though they are waiting all around, the singer recognizes that he must keep moving forward despite the obstacles. In the end, he decides that the only way to keep going is to keep pursuing great things while these “vultures” keep looking for scraps.

Overall, the song is about the constant struggles that people face in their everyday lives, and the drive and motivation needed to keep going when the world is fighting against you. The lyrics discuss taking on challenges head-on and not giving up when things are tough, themes that many listeners have found relatable and inspiring.