Gaffigan first began performing stand up comedy on January 27, 1991 in New York City. In 2000 he had a short-lived series on CBS called Welcome to New York, which co-starred Christine Baranski (Cybill) and Sara Gilbert (Roseanne). The following year, Gaffigan starred in Ellen DeGeneres' short-lived second sitcom, called The Ellen Show. In 2003/2004 he appeared in several episodes of the television show That '70s Show. Gaffigan has also appeared in the movie Super Troopers.
In 2006, Jim Gaffigan appeared on Comedy Central in a special entitled Beyond the Pale. It aired January 29, 2006, and became available for purchase on DVD that same day. "Beyond the Pale" is Gaffigan's first DVD. Jim Gaffigan also appeared on Comedy Central in his own episode of Comedy Central Presents.
In the United States, he has also appeared in Sierra Mist, Rolling Rock, and Saturn television commercials.
Gaffigan has appeared on Late Night with Conan O'Brien numerous times, often bringing episodes of Pale Force, a comedic short featuring a superhero duo (Gaffigan and O'Brien) and highlighting their mutual paleness.
On Novemeber 28th, 2006 Jim Gaffigan starred as Andy Franklin in the pilot episode of the TBS orginal series, "My Boys". comedy stand-up stand-up comedy seen live funny